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KMID : 0374920170380010015
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Inje Medical Journal
2017 Volume.38 No. 1 p.15 ~ p.23
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Cognitive Impairment in Patients with Newly Diagnosed Parkinson’s Disease
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Kim Sang-Jin
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Abstract
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Objectives: Parkinson’s disease (PD) is an increasing chronic neurodegenerative disease recently. Although it is usually diagnosed by motor symptoms, cognitive impairment which is one of the representative non-motor symptoms of PD became noticeable factor determining the patient’s quality of life. Several factors such as age, onset age of disease, and years of education have been reported to be the affecting factors but not clearly proved to have relationship with the severity of the cognitive impairment. The purpose of this research is to analyze the proportion of mild cognitive impairment (MCI) and dementia in patients with newly diagnosed PD and to evaluate the relationships between the severities of the cognitive impairment with the several factors.
Methods: Subjects were enrolled in Parkinson disease center of Busan Paik Hospital. The assessment of patients included the Mini-mental state examination (MMSE), the Montreal cognitive assessment (MoCA), and the Seoul Neuropsychological Screening Battery (SNSB). The DSM-III-R and Petersen's criteria are used to diagnose dementia and subtypes of MCI, respectively. Frequency analysis was used to analyze the frequencies of cognitive impairments in PD patients and linear regression analysis was applied to analyze factors which affected the results of MoCA.
Results: Sixty-five newly diagnosed PD patients were selected. 43 of them were cognitively intact, Twenty patient were diagnosed with MCI (single domain amnestic MCI=5, single domain non-amnestic MCI=8, multiple domain amnestic MCI=5, multiple domain non-amnestic MCI=2), and 2 patients were diagnosed with dementia. In multivariate analysis, the years of education (p=0.01) and the Frontal Assessment Battery (FAB) (p=0.03) were related to the results of MoCA scores.
Conclusion: Thirty percent of the newly diagnosed PD patients had MCI. The years of education and FAB are affecting factors to global cognitive function which is assessed with MoCA. However, these findings should be interpreted with caution due to the relatively small number of subjects included in this study.
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KEYWORD
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Parkinson’s disease, Mild cognitive impairment, Dementia
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